{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(12)"],"submitter":["Kuduk SD"],"pubmed_abstract":["Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy."],"journal":["ACS medicinal chemistry letters"],"pagination":["1070-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025801"],"repository":["biostudies-literature"],"pubmed_title":["Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators."],"pmcid":["PMC4025801"],"pubmed_authors":["Koeplinger KA","Greshock TJ","Ray WJ","Bilodeau MT","Ma L","Kuduk SD","Seager MA","Hartman GD","Chang RK","Wittmann M","Thompson CD"],"additional_accession":[]},"is_claimable":false,"name":"Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.","description":"Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Dec","modification":"2025-04-04T08:41:43.792Z","creation":"2019-03-27T01:28:29Z"},"accession":"S-EPMC4025801","cross_references":{"pubmed":["24900430"],"doi":["10.1021/ml300280g"]}}