biostudies-literatureUnknown3(12)Kuduk SDSelective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy.ACS medicinal chemistry letters1070-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025801biostudies-literatureIdentification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.PMC4025801Koeplinger KAGreshock TJRay WJBilodeau MTMa LKuduk SDSeager MAHartman GDChang RKWittmann MThompson CDfalseIdentification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy.2012-01-01T00:00:00Z2012 Dec2025-04-04T08:41:43.792Z2019-03-27T01:28:29ZS-EPMC40258012490043010.1021/ml300280g