{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(2)"],"submitter":["Moser D"],"pubmed_abstract":["Dual-target inhibitors gained increased attention in the past years. A novel in silico approach was employed for the discovery of dual 5-lipoxygenase/soluble epoxide hydrolase inhibitors. The ligand-based approach uses excessive pharmacophore elucidation and pharmacophore alignment in conjunction with shape-based scoring. The virtual screening results were verified in vitro, leading to nine novel inhibitors including a dual-target compound."],"journal":["ACS medicinal chemistry letters"],"pagination":["155-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025812"],"repository":["biostudies-literature"],"pubmed_title":["Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering."],"pmcid":["PMC4025812"],"pubmed_authors":["Klingler FM","Wisniewska JM","Achenbach J","Steinhilber D","Hahn S","Proschak E","Hofmann B","Moser D","Buscato El"],"additional_accession":[]},"is_claimable":false,"name":"Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.","description":"Dual-target inhibitors gained increased attention in the past years. A novel in silico approach was employed for the discovery of dual 5-lipoxygenase/soluble epoxide hydrolase inhibitors. The ligand-based approach uses excessive pharmacophore elucidation and pharmacophore alignment in conjunction with shape-based scoring. The virtual screening results were verified in vitro, leading to nine novel inhibitors including a dual-target compound.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Feb","modification":"2025-04-04T08:41:46.266Z","creation":"2019-03-27T01:28:29Z"},"accession":"S-EPMC4025812","cross_references":{"pubmed":["24900445"],"doi":["10.1021/ml200286e"]}}