biostudies-literatureUnknown3(2)Moser DDual-target inhibitors gained increased attention in the past years. A novel in silico approach was employed for the discovery of dual 5-lipoxygenase/soluble epoxide hydrolase inhibitors. The ligand-based approach uses excessive pharmacophore elucidation and pharmacophore alignment in conjunction with shape-based scoring. The virtual screening results were verified in vitro, leading to nine novel inhibitors including a dual-target compound.ACS medicinal chemistry letters155-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025812biostudies-literatureDual-target virtual screening by pharmacophore elucidation and molecular shape filtering.PMC4025812Klingler FMWisniewska JMAchenbach JSteinhilber DHahn SProschak EHofmann BMoser DBuscato ElfalseDual-target virtual screening by pharmacophore elucidation and molecular shape filtering.Dual-target inhibitors gained increased attention in the past years. A novel in silico approach was employed for the discovery of dual 5-lipoxygenase/soluble epoxide hydrolase inhibitors. The ligand-based approach uses excessive pharmacophore elucidation and pharmacophore alignment in conjunction with shape-based scoring. The virtual screening results were verified in vitro, leading to nine novel inhibitors including a dual-target compound.2012-01-01T00:00:00Z2012 Feb2025-04-04T08:41:46.266Z2019-03-27T01:28:29ZS-EPMC40258122490044510.1021/ml200286e