{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(5)"],"submitter":["Armirotti A"],"pubmed_abstract":["The cysteine amidase N-acylethanolamine acid amidase (NAAA) is a member of the N-terminal nucleophile class of enzymes and a potential target for anti-inflammatory drugs. We investigated the mechanism of inhibition of human NAAA by substituted β-lactones. We characterized pharmacologically a representative member of this class, ARN077, and showed, using high-resolution liquid chromatography-tandem mass spectrometry, that this compound forms a thioester bond with the N-terminal catalytic cysteine in human NAAA."],"journal":["ACS medicinal chemistry letters"],"pagination":["422-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025845"],"repository":["biostudies-literature"],"pubmed_title":["β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine."],"pmcid":["PMC4025845"],"pubmed_authors":["Karacsonyi C","Bertozzi F","Tarzia G","Ponzano S","Romeo E","Dionisi M","Garau G","Tarozzo G","Bandiera T","Mor M","Armirotti A","Mengatto L","Piomelli D","Reggiani A"],"additional_accession":[]},"is_claimable":false,"name":"β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.","description":"The cysteine amidase N-acylethanolamine acid amidase (NAAA) is a member of the N-terminal nucleophile class of enzymes and a potential target for anti-inflammatory drugs. We investigated the mechanism of inhibition of human NAAA by substituted β-lactones. We characterized pharmacologically a representative member of this class, ARN077, and showed, using high-resolution liquid chromatography-tandem mass spectrometry, that this compound forms a thioester bond with the N-terminal catalytic cysteine in human NAAA.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2025-04-04T08:41:59.8Z","creation":"2019-03-27T01:28:29Z"},"accession":"S-EPMC4025845","cross_references":{"pubmed":["24900487"],"doi":["10.1021/ml300056y"]}}