{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(10)"],"submitter":["Keith JM"],"pubmed_abstract":["A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates."],"journal":["ACS medicinal chemistry letters"],"pagination":["823-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4025847"],"repository":["biostudies-literature"],"pubmed_title":["Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate."],"pmcid":["PMC4025847"],"pubmed_authors":["Chang L","Wilson S","Wennerholm M","Scott B","Chaplan S","Pierce J","Xiao W","Webb M","Rizzolio M","Keith JM","Apodaca R","Seierstad M","Tichenor M","Luo L","Rynberg R","Breitenbucher JG","Jones W","Palmer J","Karbarz M","Brown S"],"additional_accession":[]},"is_claimable":false,"name":"Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.","description":"A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and cynomolgous monkey. The elevation of the levels of these lipids in the plasma of monkeys suggests that FAAH-2 may not play a significant role in regulating plasma levels of fatty acid ethanolamides in primates.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Oct","modification":"2025-04-04T08:41:59.252Z","creation":"2019-03-27T01:28:29Z"},"accession":"S-EPMC4025847","cross_references":{"pubmed":["24900385"],"doi":["10.1021/ml300186g"]}}