{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Xu J"],"pubmed_abstract":["Background Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that is activated by fibrillar collagens. Although DDR2 contributes to the metastasis of some tumors, its role in head and neck squamous cell carcinoma (HNSCC) remains unknown. The aim of this study was to investigate the expression level, clinical and pathological significance, and biologic function of DDR2 in HNSCC. Methods Real-time quantitative PCR, western blot, and immunohistochemical staining were employed to assess the expression levels of DDR2 in HNSCC specimens. Adenovirus-mediated overexpression of DDR2 was used to evaluate its consequences on cell proliferation, invasion, migration, and the process of hypoxia-induced epithelial-mesenchymal transition (EMT). Then nude mouse xenograft and tai"],"journal":["Cancer biology & therapy"],"pagination":["612-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4026084"],"repository":["biostudies-literature"],"pubmed_title":["Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma."],"pmcid":["PMC4026084"],"pubmed_authors":["Liu Y","Lu W","Su J","Zhang S","Ren T","Xu J","Zhu T","Zhu C","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma.","description":"Background Discoidin domain receptor 2 (DDR2) is a unique receptor tyrosine kinase (RTK) that is activated by fibrillar collagens. Although DDR2 contributes to the metastasis of some tumors, its role in head and neck squamous cell carcinoma (HNSCC) remains unknown. The aim of this study was to investigate the expression level, clinical and pathological significance, and biologic function of DDR2 in HNSCC. Methods Real-time quantitative PCR, western blot, and immunohistochemical staining were employed to assess the expression levels of DDR2 in HNSCC specimens. Adenovirus-mediated overexpression of DDR2 was used to evaluate its consequences on cell proliferation, invasion, migration, and the process of hypoxia-induced epithelial-mesenchymal transition (EMT). Then nude mouse xenograft and tai","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-04T08:41:57.792Z","creation":"2019-03-27T01:28:30Z"},"accession":"S-EPMC4026084","cross_references":{"pubmed":["24556606"],"doi":["10.4161/cbt.28181"]}}