biostudies-literatureUnknown9(3)Monteiro JPMicronutrient research typically focuses on analyzing the effects of single or a few nutrients on health by analyzing a limited number of biomarkers. The observational study described here analyzed micronutrients, plasma proteins, dietary intakes, and genotype using a systems approach. Participants attended a community-based summer day program for 6-14 year old in 2 years. Genetic makeup, blood metabolite and protein levels, and dietary differences were measured in each individual. Twenty-four-hour dietary intakes, eight micronutrients (vitamins A, D, E, thiamin, folic acid, riboflavin, pyridoxal, and pyridoxine) and 3 one-carbon metabolites [homocysteine (Hcy), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)], and 1,129 plasma proteins were analyzed as a function of diet at mGenes & nutrition403https://www.ebi.ac.uk/biostudies/studies/S-EPMC4026438biostudies-literatureMethylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study.PMC4026438Champagne CPriami CNing BBogle MMcCabe-Sellers BOguntimein JBeger RDMorine MJWilliams APence LMonteiro JPTaylor LTeitel CWise CTurner JToennessen TShelby BKaput JfalseMethylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study.Micronutrient research typically focuses on analyzing the effects of single or a few nutrients on health by analyzing a limited number of biomarkers. The observational study described here analyzed micronutrients, plasma proteins, dietary intakes, and genotype using a systems approach. Participants attended a community-based summer day program for 6-14 year old in 2 years. Genetic makeup, blood metabolite and protein levels, and dietary differences were measured in each individual. Twenty-four-hour dietary intakes, eight micronutrients (vitamins A, D, E, thiamin, folic acid, riboflavin, pyridoxal, and pyridoxine) and 3 one-carbon metabolites [homocysteine (Hcy), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH)], and 1,129 plasma proteins were analyzed as a function of diet at m2014-01-01T00:00:00Z2014 May2026-04-18T09:11:40.212Z2026-04-07T14:35:39.064ZS-EPMC40264382476055310.1007/s12263-014-0403-9