{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Gupta N"],"pubmed_abstract":["This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of a new compound, named Retro-2.1, active against toxins by inhibiting intracellular trafficking via the retrograde route. The absolute configuration of the bioactive enantiomer has been assigned from X-ray diffraction to the (S)-enantiomer. To date, (S)-Retro-2.1 is the most potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin, with EC50 values of 23 and 54 nM, respectively."],"journal":["ACS medicinal chemistry letters"],"pagination":["94-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4027625"],"repository":["biostudies-literature"],"pubmed_title":["(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins."],"pmcid":["PMC4027625"],"pubmed_authors":["Buisson DA","Cintrat JC","Johannes L","Pons V","Michau A","Gillet D","Gupta N","Barbier J","Noel R"],"additional_accession":[]},"is_claimable":false,"name":"(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins.","description":"This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of a new compound, named Retro-2.1, active against toxins by inhibiting intracellular trafficking via the retrograde route. The absolute configuration of the bioactive enantiomer has been assigned from X-ray diffraction to the (S)-enantiomer. To date, (S)-Retro-2.1 is the most potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin, with EC50 values of 23 and 54 nM, respectively.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2025-04-22T17:37:41.637Z","creation":"2019-03-27T01:28:35Z"},"accession":"S-EPMC4027625","cross_references":{"pubmed":["24900779"],"doi":["10.1021/ml400457j"]}}