{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martinu T"],"funding":["NCRR NIH HHS","NHLBI NIH HHS","PHS HHS"],"pagination":["e97951"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4028236"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["Background
Pulmonary GVHD (pGVHD) is an important complication of hematopoietic cell transplant (HCT) and is thought to be a consequence of the HCT conditioning regimen, allogeneic donor cells, and posttransplant lung exposures. We have previously demonstrated that serial inhaled lipopolysaccharide (LPS) exposures potentiate the development of pGVHD after murine allogeneic HCT. In the current study we hypothesized that allogeneic lymphocytes and environmental exposures alone, in the absence of a pre-conditioning regimen, would cause features of pGVHD and would lead to a different T cell expansion pattern compared to syngeneic cells.Methods
Recipient Rag1-/- mice received a transfer of allogeneic (Allo) or syngeneic (Syn) spleen cells. After 1 week of immune reconstitution, "],"journal":["PloS one"],"pubmed_title":["Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease."],"pmcid":["PMC4028236"],"funding_grant_id":["NIH/NHLBI 1P50-HL084917-01","P50 HL084917","K24 HL091140","NIH 1 K24HL91140-01A2","RR024 127-03"],"pubmed_authors":["Palmer SM","Foster WM","Martinu T","Kelly FL","Nelson ME","Garantziotis S","Sun J","Kinnier CV"],"additional_accession":[]},"is_claimable":false,"name":"Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.","description":"Background
Pulmonary GVHD (pGVHD) is an important complication of hematopoietic cell transplant (HCT) and is thought to be a consequence of the HCT conditioning regimen, allogeneic donor cells, and posttransplant lung exposures. We have previously demonstrated that serial inhaled lipopolysaccharide (LPS) exposures potentiate the development of pGVHD after murine allogeneic HCT. In the current study we hypothesized that allogeneic lymphocytes and environmental exposures alone, in the absence of a pre-conditioning regimen, would cause features of pGVHD and would lead to a different T cell expansion pattern compared to syngeneic cells.Methods
Recipient Rag1-/- mice received a transfer of allogeneic (Allo) or syngeneic (Syn) spleen cells. After 1 week of immune reconstitution, ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-05-29T15:59:32.473Z","creation":"2025-05-29T15:59:32.473Z"},"accession":"S-EPMC4028236","cross_references":{"pubmed":["24844383"],"doi":["10.1371/journal.pone.0097951"]}}