{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matsuda R"],"funding":["NCRR NIH HHS","NIDDK NIH HHS","National Institutes of Health","NIH","NIGMS NIH HHS"],"pagination":["48-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4032809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["966"],"pubmed_abstract":["The study of metabolomics can provide valuable information about biochemical pathways and processes at the molecular level. There have been many reports that have examined the structure, identity and concentrations of metabolites in biological systems. However, the binding of metabolites with proteins is also of growing interest. This review examines past reports that have looked at the binding of various types of metabolites with proteins. An overview of the techniques that have been used to characterize and study metabolite-protein binding is first provided. This is followed by examples of studies that have investigated the binding of hormones, fatty acids, drugs or other xenobiotics, and their metabolites with transport proteins and receptors. These examples include reports that have co"],"journal":["Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"],"pubmed_title":["Studies of metabolite-protein interactions: a review."],"pmcid":["PMC4032809"],"funding_grant_id":["RR015468-01","C06 RR015468","R01 GM044931 and R01 DK069629","R01 DK069629","R01 GM044931"],"pubmed_authors":["Zheng X","Bi C","Matsuda R","Hage DS","Vargas Badilla J","Rodriguez E","Anguizola J","Sobansky M","Hage B"],"additional_accession":[]},"is_claimable":false,"name":"Studies of metabolite-protein interactions: a review.","description":"The study of metabolomics can provide valuable information about biochemical pathways and processes at the molecular level. There have been many reports that have examined the structure, identity and concentrations of metabolites in biological systems. However, the binding of metabolites with proteins is also of growing interest. This review examines past reports that have looked at the binding of various types of metabolites with proteins. An overview of the techniques that have been used to characterize and study metabolite-protein binding is first provided. This is followed by examples of studies that have investigated the binding of hormones, fatty acids, drugs or other xenobiotics, and their metabolites with transport proteins and receptors. These examples include reports that have co","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-04T12:58:23.685Z","creation":"2019-06-06T12:48:40Z"},"accession":"S-EPMC4032809","cross_references":{"pubmed":["24321277"],"doi":["10.1016/j.jchromb.2013.11.043"]}}