{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Dai Q"],"pubmed_abstract":["<h4>Background</h4>Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA.<h4>Results</h4>To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression of"],"journal":["BMC genomics"],"pagination":["333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4035064"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA profiling of rats with ochratoxin A nephrotoxicity."],"pmcid":["PMC4035064"],"pubmed_authors":["Guo M","Dweep H","Xia K","Cheng WH","Dai Q","Qi X","Gretz N","He X","Luo Y","Huang K","Zhao J","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA profiling of rats with ochratoxin A nephrotoxicity.","description":"<h4>Background</h4>Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA.<h4>Results</h4>To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression of","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-05-03T11:02:14.471Z","creation":"2019-03-27T01:28:54Z"},"accession":"S-EPMC4035064","cross_references":{"pubmed":["24885635"],"doi":["10.1186/1471-2164-15-333"]}}