biostudies-literatureUnknown15Dai Q<h4>Background</h4>Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA.<h4>Results</h4>To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression ofBMC genomics333https://www.ebi.ac.uk/biostudies/studies/S-EPMC4035064biostudies-literatureMicroRNA profiling of rats with ochratoxin A nephrotoxicity.PMC4035064Guo MDweep HXia KCheng WHDai QQi XGretz NHe XLuo YHuang KZhao JXu WfalseMicroRNA profiling of rats with ochratoxin A nephrotoxicity.<h4>Background</h4>Nephrotoxicity is the most prominent one among the various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range of biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA.<h4>Results</h4>To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatment. A total of 409 known miRNAs and 8 novel miRNAs were identified in the kidney and the levels of the novel miRNAs were varied in response to different doses of OTA. Expression of2014-01-01T00:00:00Z2014 May2026-05-03T11:02:14.471Z2019-03-27T01:28:54ZS-EPMC40350642488563510.1186/1471-2164-15-333