biostudies-literatureUnknown9(5)Tho NV<h4>Background</h4>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.<h4>Methods</h4>Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensiPloS onee98335https://www.ebi.ac.uk/biostudies/studies/S-EPMC4035347biostudies-literatureAirway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers.PMC4035347Higami YMurakami YOgawa ELan le TTTho NVNakagawa HKanda RNagao TGoto KOguma TSeto RRyujin YNakano YTrang le THFukunaga KYamaguchi MfalseAirway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers.<h4>Background</h4>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.<h4>Methods</h4>Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensi2014-01-01T00:00:00Z20142025-04-22T00:10:51.429Z2019-03-26T23:26:06ZS-EPMC40353472486566110.1371/journal.pone.0098335