{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harmon QE"],"funding":["NICHD NIH HHS","NCRR NIH HHS","NIEHS NIH HHS"],"pagination":["472-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4040534"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(5)"],"pubmed_abstract":["<h4>Problem</h4>Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.<h4>Method of study</h4>Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.<h4>Results</h4>Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8"],"journal":["American journal of reproductive immunology (New York, N.Y. : 1989)"],"pubmed_title":["Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia."],"pmcid":["PMC4040534"],"funding_grant_id":["HD37584","T32 ES007018","P30 ES010126","HD28684A","P2C HD050924","R01 HD039373","2-T32-ES07018","R01 HD037584","RR00046","HD28684","P30ES010126","R21 HD060207","M01 RR000046","HD39373"],"pubmed_authors":["Avery CL","Luo J","Stuebe AM","Harmon QE","Engel SM","Wu MC","Moran TM","Olshan AF"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.","description":"<h4>Problem</h4>Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.<h4>Method of study</h4>Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.<h4>Results</h4>Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-05-02T05:33:37.866Z","creation":"2019-03-27T01:29:13Z"},"accession":"S-EPMC4040534","cross_references":{"pubmed":["24702779"],"doi":["10.1111/aji.12241"]}}