biostudies-literatureHarmon QENICHD NIH HHSNCRR NIH HHSNIEHS NIH HHS472-84https://www.ebi.ac.uk/biostudies/studies/S-EPMC4040534biostudies-literatureUnknown71(5)<h4>Problem</h4>Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.<h4>Method of study</h4>Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.<h4>Results</h4>Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8American journal of reproductive immunology (New York, N.Y. : 1989)Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.PMC4040534HD37584T32 ES007018P30 ES010126HD28684AP2C HD050924R01 HD0393732-T32-ES07018R01 HD037584RR00046HD28684P30ES010126R21 HD060207M01 RR000046HD39373Avery CLLuo JStuebe AMHarmon QEEngel SMWu MCMoran TMOlshan AFfalsePolymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.<h4>Problem</h4>Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.<h4>Method of study</h4>Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.<h4>Results</h4>Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.82014-01-01T00:00:00Z2014 May2026-05-02T05:33:37.866Z2019-03-27T01:29:13ZS-EPMC40405342470277910.1111/aji.12241