biostudies-literatureNeri LShire138-47https://www.ebi.ac.uk/biostudies/studies/S-EPMC4040810biostudies-literatureUnknown2(2)<h4>Objective</h4>We sought to evaluate the association between constipation severity, productivity losses and healthcare utilization in a national sample of Italian patients with chronic non-organic constipation (CC).<h4>Methods</h4>We enrolled 878 outpatients with CC. Clinical and demographic data were collected by physicians during clinical examinations. Patients completed a self-administered questionnaire (Patient Assessment of Constipation-Symptoms, PAC-SYM; Work Productivity and Activity Impairment; healthcare utilization, and Symptoms Checklist 90 Revised - Somatization Scale, SCL-90 R).<h4>Results</h4>Mean PAC-SYM score was 1.62 ± 0.69. Mean weekly sick time due to constipation was 2.7 ± 8.6 h and productivity losses due to presenteeism was 19.7% ± 22.3%. Adjusted productivity lossUnited European gastroenterology journalConstipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation.PMC4040810DoxaPharmaAltomare DFDel Piano MPassaretti SNoris RLuzza FSavarino VCicala MFries WBenini LGaleazzi FPilotto AStanghellini VCorsetti MGuarnieri GGiangregorio FBasilisco GNeri LAnnese ACorazziari EBazzocchi GCipolletta LLo Cascio MOrselli SBellini MBattaglia EComandini GPazzi PVirgilio CCuomo RLIRS Study GroupMiraglia SPortincasa PMacarri GBocchini RBendia EBonventre SNeri MCConio MValle CCrotta SDi Stefano MTammaro LCannizzaro RSablich RUsai Satta PBassotti GGrassini MPerelli IAndriulli ACogliandro RDi Mario FfalseConstipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation.<h4>Objective</h4>We sought to evaluate the association between constipation severity, productivity losses and healthcare utilization in a national sample of Italian patients with chronic non-organic constipation (CC).<h4>Methods</h4>We enrolled 878 outpatients with CC. Clinical and demographic data were collected by physicians during clinical examinations. Patients completed a self-administered questionnaire (Patient Assessment of Constipation-Symptoms, PAC-SYM; Work Productivity and Activity Impairment; healthcare utilization, and Symptoms Checklist 90 Revised - Somatization Scale, SCL-90 R).<h4>Results</h4>Mean PAC-SYM score was 1.62 ± 0.69. Mean weekly sick time due to constipation was 2.7 ± 8.6 h and productivity losses due to presenteeism was 19.7% ± 22.3%. Adjusted productivity loss2014-01-01T00:00:00Z2014 Apr2025-04-18T21:25:41.79Z2019-03-27T01:29:15ZS-EPMC40408102495309710.1177/2050640614528175