{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Duan Y"],"pubmed_abstract":["<h4>Background</h4>microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence suggests miR-24 plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive. This study examined the role of miR-24 in gastric cancer (GC).<h4>Methods</h4>The expression of miR-24 in GC tissues compared with matched non-tumor tissues and GC cells was detected by qRT-PCR. Synthetic short single or double stranded RNA oligonucleotides and lentiviral vectors were used to regulate miR-24 expression in GC cells to investigate its function in vitro and in vivo.<h4>Results</h4>miR-24 was significantly downregulated in GC tissues compared with matched non-tumor tissues and was associated with tumor differentiation. Ectopic expression of miR-24 in SGC-7901 GC cells suppressed cell proliferation, migration and invasion in vitro as well as tumorigenicity in vivo by inducing cell cycle arrest in G0/G1 phase and promoting cell apoptosis. Furthermore, we identified RegIV as a target of miR-24 and demonstrated that miR-24 regulated RegIV expression via binding its 3' untranslated region.<h4>Conclusions</h4>miR-24 functions as a novel tumor suppressor in GC and the anti-oncogenic activity may involve its inhibition of the target gene RegIV. These findings suggest the possibility for miR-24 as a therapeutic target in GC."],"journal":["Molecular cancer"],"pagination":["127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4041902"],"repository":["biostudies-literature"],"pubmed_title":["Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV."],"pmcid":["PMC4041902"],"pubmed_authors":["Yan M","Li J","Yu B","Li C","Zhu Z","Su L","Liu B","Hu L","Yang Q","Xiang M","Duan Y","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.","description":"<h4>Background</h4>microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence suggests miR-24 plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive. This study examined the role of miR-24 in gastric cancer (GC).<h4>Methods</h4>The expression of miR-24 in GC tissues compared with matched non-tumor tissues and GC cells was detected by qRT-PCR. Synthetic short single or double stranded RNA oligonucleotides and lentiviral vectors were used to regulate miR-24 expression in GC cells to investigate its function in vitro and in vivo.<h4>Results</h4>miR-24 was significantly downregulated in GC tissues compared with matched non-tumor tissues and was associated with tumor differentiation. Ectopic expression of miR-24 in SGC-7901 GC cells suppressed cell proliferation, migration and invasion in vitro as well as tumorigenicity in vivo by inducing cell cycle arrest in G0/G1 phase and promoting cell apoptosis. Furthermore, we identified RegIV as a target of miR-24 and demonstrated that miR-24 regulated RegIV expression via binding its 3' untranslated region.<h4>Conclusions</h4>miR-24 functions as a novel tumor suppressor in GC and the anti-oncogenic activity may involve its inhibition of the target gene RegIV. These findings suggest the possibility for miR-24 as a therapeutic target in GC.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-21T20:10:29.693Z","creation":"2019-03-27T01:29:19Z"},"accession":"S-EPMC4041902","cross_references":{"pubmed":["24886316"],"doi":["10.1186/1476-4598-13-127"]}}