{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["da Silveira JC"],"pubmed_abstract":["<h4>Background</h4>Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell communication was described involving cell-secreted vesicles called exosomes (50-150 nm), which contain miRNAs and protein, and have been identified in ovarian follicular fluid. The goal of this study was to identify a possible role of exosomes in follicle maturation.<h4>Methods</h4>Follicle contents were collected from mares at mid-estrous (~35 mm, before induction of follicular maturation) and pre-ovulatory follicles (30-34 h after induction of follicular maturation). A real time PCR screen was conducted to reveal significant differences in the presence of exosomal miRNAs isolated from mid-estrous and pre-ovulatory follicles"],"journal":["Reproductive biology and endocrinology : RB&E"],"pagination":["44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4045866"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare."],"pmcid":["PMC4045866"],"pubmed_authors":["da Silveira JC","Bouma GJ","Carnevale EM","Winger QA"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare.","description":"<h4>Background</h4>Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell communication was described involving cell-secreted vesicles called exosomes (50-150 nm), which contain miRNAs and protein, and have been identified in ovarian follicular fluid. The goal of this study was to identify a possible role of exosomes in follicle maturation.<h4>Methods</h4>Follicle contents were collected from mares at mid-estrous (~35 mm, before induction of follicular maturation) and pre-ovulatory follicles (30-34 h after induction of follicular maturation). A real time PCR screen was conducted to reveal significant differences in the presence of exosomal miRNAs isolated from mid-estrous and pre-ovulatory follicles","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-04-07T16:16:07.974Z","creation":"2025-05-31T23:46:20.48Z"},"accession":"S-EPMC4045866","cross_references":{"pubmed":["24884710"],"doi":["10.1186/1477-7827-12-44"]}}