biostudies-literatureUnknown12da Silveira JC<h4>Background</h4>Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell communication was described involving cell-secreted vesicles called exosomes (50-150 nm), which contain miRNAs and protein, and have been identified in ovarian follicular fluid. The goal of this study was to identify a possible role of exosomes in follicle maturation.<h4>Methods</h4>Follicle contents were collected from mares at mid-estrous (~35 mm, before induction of follicular maturation) and pre-ovulatory follicles (30-34 h after induction of follicular maturation). A real time PCR screen was conducted to reveal significant differences in the presence of exosomal miRNAs isolated from mid-estrous and pre-ovulatory folliclesReproductive biology and endocrinology : RB&E44https://www.ebi.ac.uk/biostudies/studies/S-EPMC4045866biostudies-literatureRegulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare.PMC4045866da Silveira JCBouma GJCarnevale EMWinger QAfalseRegulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare.<h4>Background</h4>Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell communication was described involving cell-secreted vesicles called exosomes (50-150 nm), which contain miRNAs and protein, and have been identified in ovarian follicular fluid. The goal of this study was to identify a possible role of exosomes in follicle maturation.<h4>Methods</h4>Follicle contents were collected from mares at mid-estrous (~35 mm, before induction of follicular maturation) and pre-ovulatory follicles (30-34 h after induction of follicular maturation). A real time PCR screen was conducted to reveal significant differences in the presence of exosomal miRNAs isolated from mid-estrous and pre-ovulatory follicles2014-01-01T00:00:00Z2014 May2026-04-07T16:16:07.974Z2025-05-31T23:46:20.48ZS-EPMC40458662488471010.1186/1477-7827-12-44