biostudies-literatureSoland MANHLBI NIH HHS820-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC4046334biostudies-literatureUnknown14(4)Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality among both solid organ and hematopoietic stem cell transplant recipients. Identification of cells throughout the body that can potentially serve as a viral reservoir is essential to dissect mechanisms of cell tropism and latency and to develop novel therapies. Here, we tested and compared the permissivity of liver-, brain-, lung (LNG)- and bone marrow (BM)-derived perivascular mesenchymal stromal cells (MSC) to HCMV infection and their ability to propagate and produce infectious virus. Perivascular MSC isolated from the different organs have in common the expression of CD146 and Stro-1. While all these cells were permissive to HCMV infection, the highest rate of HCMV infection was seen with LNG-MSC, as American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsPerivascular stromal cells as a potential reservoir of human cytomegalovirus.PMC4046334R01 HL097623HL97623Keyes LRAlmeida-Porada GSoland MAPorada CDSt Jeor SBayne RMoon JfalsePerivascular stromal cells as a potential reservoir of human cytomegalovirus.Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality among both solid organ and hematopoietic stem cell transplant recipients. Identification of cells throughout the body that can potentially serve as a viral reservoir is essential to dissect mechanisms of cell tropism and latency and to develop novel therapies. Here, we tested and compared the permissivity of liver-, brain-, lung (LNG)- and bone marrow (BM)-derived perivascular mesenchymal stromal cells (MSC) to HCMV infection and their ability to propagate and produce infectious virus. Perivascular MSC isolated from the different organs have in common the expression of CD146 and Stro-1. While all these cells were permissive to HCMV infection, the highest rate of HCMV infection was seen with LNG-MSC, as 2014-01-01T00:00:00Z2014 Apr2025-04-05T14:29:51.901Z2019-03-27T01:29:29ZS-EPMC40463342459282210.1111/ajt.12642