{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(5)"],"submitter":["Klein J"],"pubmed_abstract":["Synthetic biology has been heralded as a new bioengineering platform for the production of bulk and specialty chemicals, drugs, and fuels. Here, we report for the first time a series of 74 novel compounds produced using a combinatorial genetics approach in baker's yeast. Based on the concept of \"coevolution\" with target proteins in an intracellular primary survival assay, the identified, mostly scaffold-sized (200-350 MW) compounds, which displayed excellent biological activity, can be considered as prevalidated hits. Of the molecules found, >75% have not been described previously; 20% of the compounds exhibit novel scaffolds. Their structural and physicochemical properties comply with established rules of drug- and fragment-likeness and exhibit increased structural complexities compared t"],"journal":["ACS synthetic biology"],"pagination":["314-23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4046787"],"repository":["biostudies-literature"],"pubmed_title":["Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery."],"pmcid":["PMC4046787"],"pubmed_authors":["Boussemghoune T","Heal JR","Tange TO","Heim J","Hamilton WD","Hatsch A","Klein J","Jaeschke G","Delegrange F"],"additional_accession":[]},"is_claimable":false,"name":"Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery.","description":"Synthetic biology has been heralded as a new bioengineering platform for the production of bulk and specialty chemicals, drugs, and fuels. Here, we report for the first time a series of 74 novel compounds produced using a combinatorial genetics approach in baker's yeast. Based on the concept of \"coevolution\" with target proteins in an intracellular primary survival assay, the identified, mostly scaffold-sized (200-350 MW) compounds, which displayed excellent biological activity, can be considered as prevalidated hits. Of the molecules found, >75% have not been described previously; 20% of the compounds exhibit novel scaffolds. Their structural and physicochemical properties comply with established rules of drug- and fragment-likeness and exhibit increased structural complexities compared t","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-05-03T11:07:51.3Z","creation":"2019-03-27T01:29:31Z"},"accession":"S-EPMC4046787","cross_references":{"pubmed":["24742115"],"doi":["10.1021/sb400177x"]}}