{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(20)"],"submitter":["Bazarian JJ"],"pubmed_abstract":["The objective of the current study was to determine the classification accuracy of serum S100B and apolipoprotein (apoA-I) for mild traumatic brain injury (mTBI) and abnormal initial head computed tomography (CT) scan, and to identify ethnic, racial, age, and sex variation in classification accuracy. We performed a prospective, multi-centered study of 787 patients with mTBI who presented to the emergency department within 6 h of injury and 467 controls who presented to the outpatient laboratory for routine blood work. Serum was analyzed for S100B and apoA-I. The outcomes were disease status (mTBI or control) and initial head CT scan. At cutoff values defined by 90% of controls, the specificity for mTBI using S100B (0.899 [95% confidence interval (CI): 0.78-0.92]) was similar to that using "],"journal":["Journal of neurotrauma"],"pagination":["1747-54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4047844"],"repository":["biostudies-literature"],"pubmed_title":["Classification accuracy of serum Apo A-I and S100B for the diagnosis of mild traumatic brain injury and prediction of abnormal initial head computed tomography scan."],"pmcid":["PMC4047844"],"pubmed_authors":["Leinhart A","Bazarian JJ","Wojcik SM","He H","Moynihan R","Kiechle K","Jones C","Ellis GL","Grant WD","Triner W","Khan J","Moscati R","Mookerjee S","Blyth BJ","Secreti LM"],"additional_accession":[]},"is_claimable":false,"name":"Classification accuracy of serum Apo A-I and S100B for the diagnosis of mild traumatic brain injury and prediction of abnormal initial head computed tomography scan.","description":"The objective of the current study was to determine the classification accuracy of serum S100B and apolipoprotein (apoA-I) for mild traumatic brain injury (mTBI) and abnormal initial head computed tomography (CT) scan, and to identify ethnic, racial, age, and sex variation in classification accuracy. We performed a prospective, multi-centered study of 787 patients with mTBI who presented to the emergency department within 6 h of injury and 467 controls who presented to the outpatient laboratory for routine blood work. Serum was analyzed for S100B and apoA-I. The outcomes were disease status (mTBI or control) and initial head CT scan. At cutoff values defined by 90% of controls, the specificity for mTBI using S100B (0.899 [95% confidence interval (CI): 0.78-0.92]) was similar to that using ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Oct","modification":"2026-05-07T02:47:47.636Z","creation":"2019-03-27T01:29:36Z"},"accession":"S-EPMC4047844","cross_references":{"pubmed":["23758329"],"doi":["10.1089/neu.2013.2853"]}}