{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim BM"],"funding":["NIA NIH HHS","NIMH NIH HHS"],"pagination":["e1237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4047864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of posttranslational modifications, such as hyperphosphorylation and conformational changes. However, it has not been fully understood how tau accumulation and phosphorylation are deregulated. In the present study, we identified a novel role of death-associated protein kinase 1 (DAPK1) in the regulation of the tau protein. We found that hippocampal DAPK1 expression is markedly increased in the brains of AD patients compared with age-matched normal subjects. DAPK1 overexpression increased tau protein stability and phosphorylation at multiple AD-related sites. In contrast, inhibition"],"journal":["Cell death & disease"],"pubmed_title":["Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function."],"pmcid":["PMC4047864"],"funding_grant_id":["R24MH068855","P50 AG005134","T32AG023480","R00 AG033104","T32 AG023480","R00AG033104","R24 MH068855","P50AG05134"],"pubmed_authors":["Lee S","Zhou XZ","Hong Y","Lee TH","Kim BM","Chen CH","Kimchi A","You MH"],"additional_accession":[]},"is_claimable":false,"name":"Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.","description":"The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of posttranslational modifications, such as hyperphosphorylation and conformational changes. However, it has not been fully understood how tau accumulation and phosphorylation are deregulated. In the present study, we identified a novel role of death-associated protein kinase 1 (DAPK1) in the regulation of the tau protein. We found that hippocampal DAPK1 expression is markedly increased in the brains of AD patients compared with age-matched normal subjects. DAPK1 overexpression increased tau protein stability and phosphorylation at multiple AD-related sites. In contrast, inhibition","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-18T23:14:55.826Z","creation":"2019-03-27T01:29:36Z"},"accession":"S-EPMC4047864","cross_references":{"pubmed":["24853415"],"doi":["10.1038/cddis.2014.216"]}}