{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prebil LA"],"funding":["NCCDPHP CDC HHS","NCI NIH HHS"],"pagination":["859-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4048469"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(7)"],"pubmed_abstract":["Purpose
Pregnancy characteristics have been associated with breast cancer risk, but information is limited on their relationship with breast density. Our objective was to examine the relationship between first pregnancy characteristics and later life breast density, and whether the association is modified by genotype.Methods
The Marin Women's Study was initiated to examine breast cancer in a high-incidence mammography population (Marin County, CA). Reproductive characteristics and pregnancy information including pregnancy-induced hypertension (PIH) were self-reported at the time of mammography. Forty-seven candidate single nucleotide polymorphisms were obtained from saliva samples; seven were assessed in relation to PIH and percent fibroglandular volume (%FGV). Breast densi"],"journal":["Cancer causes & control : CCC"],"pubmed_title":["First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants."],"pmcid":["PMC4048469"],"funding_grant_id":["5H75 DP001730-2","H75 DP001730","U01 CA063740","R01 CA166945","U01 CA63740","P01 CA154292"],"pubmed_authors":["Prebil LA","Jamshidian F","Powell MJ","Ereman RR","Hurlbert MS","Benz CC","Kerlikowske K","Shepherd JA"],"additional_accession":[]},"is_claimable":false,"name":"First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants.","description":"Purpose
Pregnancy characteristics have been associated with breast cancer risk, but information is limited on their relationship with breast density. Our objective was to examine the relationship between first pregnancy characteristics and later life breast density, and whether the association is modified by genotype.Methods
The Marin Women's Study was initiated to examine breast cancer in a high-incidence mammography population (Marin County, CA). Reproductive characteristics and pregnancy information including pregnancy-induced hypertension (PIH) were self-reported at the time of mammography. Forty-seven candidate single nucleotide polymorphisms were obtained from saliva samples; seven were assessed in relation to PIH and percent fibroglandular volume (%FGV). Breast densi","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-05-04T22:44:44.781Z","creation":"2026-04-07T21:06:42.209Z"},"accession":"S-EPMC4048469","cross_references":{"pubmed":["24801045"],"doi":["10.1007/s10552-014-0386-2"]}}