{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nonaka M"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["8173-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4050563"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(22)"],"pubmed_abstract":["Identification of carbohydrate sequences that determine affinity to specific chemokines is a critical step for strategies to interfere with chemokine-mediated leukocyte trafficking. Here, we first characterized the development of allergic asthma in Tie2-dependent and inducible Ext1-knockout (Tie2-Ext1(iKO)) mice. We showed that heparan sulfate is essential for leukocyte recruitment in the peribronchial region and bronchoalveolar lavage fluid (BALF), and is crucial for induction of airway hyperresponsiveness. Our glycan microarray showed a unique affinity profile of chemokine CCL20 to substructures of heparin and heparin-like oligo/di/monosaccharides. Among them, we identified a synthetic and not naturally occurring monosaccharide, 2,4-O-di-sulfated iduronic acid (Di-S-IdoA), as a potential"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites."],"pmcid":["PMC4050563"],"funding_grant_id":["R01 AI072115","AI 107779","R01 AI107779","R37 AI038425","P01 CA071932","P01 CA71932","AI 70535","U19 AI070535","AI 38425","AI 72115","R01 AI038425"],"pubmed_authors":["Nakayama J","Fukuda M","Broide DH","Seeberger PH","Gotze S","Bao X","Matsumura F","Kononov A","Nonaka M","Kandasamy J"],"additional_accession":[]},"is_claimable":false,"name":"Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.","description":"Identification of carbohydrate sequences that determine affinity to specific chemokines is a critical step for strategies to interfere with chemokine-mediated leukocyte trafficking. Here, we first characterized the development of allergic asthma in Tie2-dependent and inducible Ext1-knockout (Tie2-Ext1(iKO)) mice. We showed that heparan sulfate is essential for leukocyte recruitment in the peribronchial region and bronchoalveolar lavage fluid (BALF), and is crucial for induction of airway hyperresponsiveness. Our glycan microarray showed a unique affinity profile of chemokine CCL20 to substructures of heparin and heparin-like oligo/di/monosaccharides. Among them, we identified a synthetic and not naturally occurring monosaccharide, 2,4-O-di-sulfated iduronic acid (Di-S-IdoA), as a potential","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-26T09:52:42.689Z","creation":"2019-03-27T01:29:47Z"},"accession":"S-EPMC4050563","cross_references":{"pubmed":["24835176"],"doi":["10.1073/pnas.1319870111"]}}