{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thrailkill K"],"funding":["NIDDK NIH HHS","NCRR NIH HHS","National Institutes of Health"],"pagination":["703589"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4052184"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2014"],"pubmed_abstract":["Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal models of T1D, suggest that the insulinopenia of T1D has a deleterious effect on bone. To further examine the action of insulin signaling on bone development, we generated mice with an osteoprogenitor-selective (osterix-Cre) ablation of the insulin receptor (IR), designated OIRKO. OIRKO mice exhibited an 80% decrease in IR in osteoblasts. Prenatal elimination of IR did not affect fetal survival or gross morphology. However, loss of IR in mouse osteoblasts resulted in a postnatal growth-constricted phenotype. By 10-12 weeks of age, femurs of OIRKO mice were more slender, with"],"journal":["Journal of diabetes research"],"pubmed_title":["Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone."],"pmcid":["PMC4052184"],"funding_grant_id":["C06 RR016517","R01 DK084045","C06RR16517","36112","R56 DK084045"],"pubmed_authors":["Cockrell G","Lumpkin C","Morris L","Kahn CR","Fowlkes J","Bunn RC","Thrailkill K","Nyman JS","Wahl E"],"additional_accession":[]},"is_claimable":false,"name":"Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.","description":"Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal models of T1D, suggest that the insulinopenia of T1D has a deleterious effect on bone. To further examine the action of insulin signaling on bone development, we generated mice with an osteoprogenitor-selective (osterix-Cre) ablation of the insulin receptor (IR), designated OIRKO. OIRKO mice exhibited an 80% decrease in IR in osteoblasts. Prenatal elimination of IR did not affect fetal survival or gross morphology. However, loss of IR in mouse osteoblasts resulted in a postnatal growth-constricted phenotype. By 10-12 weeks of age, femurs of OIRKO mice were more slender, with","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-21T18:55:36.041Z","creation":"2019-03-27T01:29:51Z"},"accession":"S-EPMC4052184","cross_references":{"pubmed":["24963495"],"doi":["10.1155/2014/703589"]}}