biostudies-literatureThrailkill KNIDDK NIH HHSNCRR NIH HHSNational Institutes of Health703589https://www.ebi.ac.uk/biostudies/studies/S-EPMC4052184biostudies-literatureUnknown2014Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal models of T1D, suggest that the insulinopenia of T1D has a deleterious effect on bone. To further examine the action of insulin signaling on bone development, we generated mice with an osteoprogenitor-selective (osterix-Cre) ablation of the insulin receptor (IR), designated OIRKO. OIRKO mice exhibited an 80% decrease in IR in osteoblasts. Prenatal elimination of IR did not affect fetal survival or gross morphology. However, loss of IR in mouse osteoblasts resulted in a postnatal growth-constricted phenotype. By 10-12 weeks of age, femurs of OIRKO mice were more slender, withJournal of diabetes researchLoss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.PMC4052184C06 RR016517R01 DK084045C06RR1651736112R56 DK084045Cockrell GLumpkin CMorris LKahn CRFowlkes JBunn RCThrailkill KNyman JSWahl EfalseLoss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal models of T1D, suggest that the insulinopenia of T1D has a deleterious effect on bone. To further examine the action of insulin signaling on bone development, we generated mice with an osteoprogenitor-selective (osterix-Cre) ablation of the insulin receptor (IR), designated OIRKO. OIRKO mice exhibited an 80% decrease in IR in osteoblasts. Prenatal elimination of IR did not affect fetal survival or gross morphology. However, loss of IR in mouse osteoblasts resulted in a postnatal growth-constricted phenotype. By 10-12 weeks of age, femurs of OIRKO mice were more slender, with2014-01-01T00:00:00Z20142025-04-21T18:55:36.041Z2019-03-27T01:29:51ZS-EPMC40521842496349510.1155/2014/703589