biostudies-literatureUnknown9(2)Marrachelli VGTo identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure measurement and albumin/creatinine ratio were measured in a urine sample. Using SNPlex, 1251 SNPs potentially associated to urinary albumin excretion (UAE) were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54 ± 19, 50.6% men, ACR>30 mg/g in 81 subjects) with high genotyping call rate were analysed. A characteristic metabolomic profile, which included products from mitochondrial and extra mitPloS onee98227https://www.ebi.ac.uk/biostudies/studies/S-EPMC4053470biostudies-literatureGenomic and metabolomic profile associated to microalbuminuria.PMC4053470Mansego MLSegura RChaves FJGalan IMartin-Escudero JCMarrachelli VGMarin PLliso GMorales JMBriongos LRedon JMonleon DMartinez FRentero PfalseGenomic and metabolomic profile associated to microalbuminuria.To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure measurement and albumin/creatinine ratio were measured in a urine sample. Using SNPlex, 1251 SNPs potentially associated to urinary albumin excretion (UAE) were analyzed. Serum metabolomic profile was assessed by 1H NMR spectra using a Brucker Advance DRX 600 spectrometer. From the total population, 1217 (mean age 54 ± 19, 50.6% men, ACR>30 mg/g in 81 subjects) with high genotyping call rate were analysed. A characteristic metabolomic profile, which included products from mitochondrial and extra mit2014-01-01T00:00:00Z20142026-05-02T20:00:10.556Z2019-03-26T23:26:12ZS-EPMC40534702491890810.1371/journal.pone.0098227