biostudies-literatureUnknown9(6)Wu Y<h4>Background</h4>Accumulating evidence suggests that hypoglycaemic agents influence lung cancer risk in patients with diabetes. It remains to be fully elucidated whether conventional hypoglycaemic agents (metformin, sulfonylureas, thiazolidinediones [TZDs] or insulin) affect lung cancer incidence in patients with diabetes.<h4>Methods</h4>We performed a meta-analysis using EMBASE, MEDLINE and Web of Science to search randomised controlled trials (RCTs), cohort studies, and case-control studies published up to October 2013 that assessed the effects of metformin, sulfonylurea, TZDs or insulin on lung cancer risk in subjects with diabetes. Fixed and random effects meta-analysis models were used, and the effect size was expressed as a summary odds ratio (OR) with 95% confidence intervals (CI)PloS onee99577https://www.ebi.ac.uk/biostudies/studies/S-EPMC4055722biostudies-literatureConventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis.PMC4055722Shi XFWu YLiu HBSong YfalseConventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis.<h4>Background</h4>Accumulating evidence suggests that hypoglycaemic agents influence lung cancer risk in patients with diabetes. It remains to be fully elucidated whether conventional hypoglycaemic agents (metformin, sulfonylureas, thiazolidinediones [TZDs] or insulin) affect lung cancer incidence in patients with diabetes.<h4>Methods</h4>We performed a meta-analysis using EMBASE, MEDLINE and Web of Science to search randomised controlled trials (RCTs), cohort studies, and case-control studies published up to October 2013 that assessed the effects of metformin, sulfonylurea, TZDs or insulin on lung cancer risk in subjects with diabetes. Fixed and random effects meta-analysis models were used, and the effect size was expressed as a summary odds ratio (OR) with 95% confidence intervals (CI)2014-01-01T00:00:00Z20142025-04-19T02:39:20.508Z2019-03-26T23:26:12ZS-EPMC40557222492477110.1371/journal.pone.0099577