{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(1)"],"submitter":["Jabandziev P"],"pubmed_abstract":["<h4>Introduction</h4>The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.<h4>Methods</h4>We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables "],"journal":["Critical care (London, England)"],"pagination":["R1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4056441"],"repository":["biostudies-literature"],"pubmed_title":["Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis."],"pmcid":["PMC4056441"],"pubmed_authors":["Michalek J","Smerek M","Hubacek JA","Fedora M","Kosinova L","Jabandziev P"],"additional_accession":[]},"is_claimable":false,"name":"Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.","description":"<h4>Introduction</h4>The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.<h4>Methods</h4>We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2026-04-29T16:20:12.204Z","creation":"2026-04-07T15:21:05.574Z"},"accession":"S-EPMC4056441","cross_references":{"pubmed":["24383711"],"doi":["10.1186/cc13174"]}}