biostudies-literatureUnknown18(1)Jabandziev P<h4>Introduction</h4>The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.<h4>Methods</h4>We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables Critical care (London, England)R1https://www.ebi.ac.uk/biostudies/studies/S-EPMC4056441biostudies-literatureMultiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.PMC4056441Michalek JSmerek MHubacek JAFedora MKosinova LJabandziev PfalseMultiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.<h4>Introduction</h4>The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.<h4>Methods</h4>We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables 2014-01-01T00:00:00Z2014 Jan2026-04-29T16:20:12.204Z2026-04-07T15:21:05.574ZS-EPMC40564412438371110.1186/cc13174