{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abou Alaiwa MH"],"funding":["Howard Hughes Medical Institute","NIEHS NIH HHS","Program Project Grant","NHLBI NIH HHS","Cystic Fibrosis Foundation Research Development Program"],"pagination":["373-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4060428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["<h4>Background</h4>Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.<h4>Methods</h4>In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.<h4>Results</h4>In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates (pH6.4 ± 0.2). In contrast, nasal pH of CF children and adults was similar to values measured in people without CF.<h4>Conclusions</h4>At an age when infection, inflammation and airway wall remodeling are minimal, neonates with CF had an acidic nasal ASL compared to babies without CF. The CF:non-CF pH difference disappeared in older individuals, perhaps because "],"journal":["Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society"],"pubmed_title":["Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study."],"pmcid":["PMC4060428"],"funding_grant_id":["R458","P01 HL091842","P30 ES005605","P01 HL051670","HL51670"],"pubmed_authors":["Abou Alaiwa MH","Launspach JL","Welsh MJ","Beer AM","Starner TD","Zabner J","Pezzulo AA","Stoltz DA","Horan RA"],"additional_accession":[]},"is_claimable":false,"name":"Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.","description":"<h4>Background</h4>Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.<h4>Methods</h4>In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.<h4>Results</h4>In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates (pH6.4 ± 0.2). In contrast, nasal pH of CF children and adults was similar to values measured in people without CF.<h4>Conclusions</h4>At an age when infection, inflammation and airway wall remodeling are minimal, neonates with CF had an acidic nasal ASL compared to babies without CF. The CF:non-CF pH difference disappeared in older individuals, perhaps because ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2025-04-21T16:57:18.623Z","creation":"2019-03-27T01:30:21Z"},"accession":"S-EPMC4060428","cross_references":{"pubmed":["24418186"],"doi":["10.1016/j.jcf.2013.12.006"]}}