biostudies-literatureAbou Alaiwa MHHoward Hughes Medical InstituteNIEHS NIH HHSProgram Project GrantNHLBI NIH HHSCystic Fibrosis Foundation Research Development Program373-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4060428biostudies-literatureUnknown13(4)<h4>Background</h4>Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.<h4>Methods</h4>In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.<h4>Results</h4>In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates (pH6.4 ± 0.2). In contrast, nasal pH of CF children and adults was similar to values measured in people without CF.<h4>Conclusions</h4>At an age when infection, inflammation and airway wall remodeling are minimal, neonates with CF had an acidic nasal ASL compared to babies without CF. The CF:non-CF pH difference disappeared in older individuals, perhaps because Journal of cystic fibrosis : official journal of the European Cystic Fibrosis SocietyNeonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.PMC4060428R458P01 HL091842P30 ES005605P01 HL051670HL51670Abou Alaiwa MHLaunspach JLWelsh MJBeer AMStarner TDZabner JPezzulo AAStoltz DAHoran RAfalseNeonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.<h4>Background</h4>Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF.<h4>Methods</h4>In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults.<h4>Results</h4>In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates (pH6.4 ± 0.2). In contrast, nasal pH of CF children and adults was similar to values measured in people without CF.<h4>Conclusions</h4>At an age when infection, inflammation and airway wall remodeling are minimal, neonates with CF had an acidic nasal ASL compared to babies without CF. The CF:non-CF pH difference disappeared in older individuals, perhaps because 2014-01-01T00:00:00Z2014 Jul2025-04-21T16:57:18.623Z2019-03-27T01:30:21ZS-EPMC40604282441818610.1016/j.jcf.2013.12.006