{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim KY"],"funding":["NEI NIH HHS","NIDCD NIH HHS","NINDS NIH HHS"],"pagination":["33-47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4060604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["268"],"pubmed_abstract":["Ca(2+) binding protein 1 (CaBP1) and caldendrin are alternatively spliced variants of a subfamily of CaBPs with high homology to calmodulin. Although CaBP1 and caldendrin regulate effectors including plasma membrane and intracellular Ca(2+) channels in heterologous expression systems, little is known about their functions in vivo. Therefore, we generated mice deficient in CaBP1/caldendrin expression (C-KO) and analyzed the expression and cellular localization of CaBP1 and caldendrin in the mouse brain. Immunoperoxidase labeling with antibodies recognizing both CaBP1 and caldendrin was absent in the brain of C-KO mice, but was intense in multiple brain regions of wild-type mice. By Western blot, the antibodies detected two proteins that were absent in the C-KO mouse and consistent in size w"],"journal":["Neuroscience"],"pubmed_title":["Localization and expression of CaBP1/caldendrin in the mouse brain."],"pmcid":["PMC4060604"],"funding_grant_id":["EY020850","R01 NS084190","DC009433","R55 DC009433","R01 EY020850","NS084190","R01 DC009433","P30 DC010362","P30 EY001730","DC010362"],"pubmed_authors":["Liu X","Lee A","Haeseleer F","Shepherd A","Kim KY","Scholl ES"],"additional_accession":[]},"is_claimable":false,"name":"Localization and expression of CaBP1/caldendrin in the mouse brain.","description":"Ca(2+) binding protein 1 (CaBP1) and caldendrin are alternatively spliced variants of a subfamily of CaBPs with high homology to calmodulin. Although CaBP1 and caldendrin regulate effectors including plasma membrane and intracellular Ca(2+) channels in heterologous expression systems, little is known about their functions in vivo. Therefore, we generated mice deficient in CaBP1/caldendrin expression (C-KO) and analyzed the expression and cellular localization of CaBP1 and caldendrin in the mouse brain. Immunoperoxidase labeling with antibodies recognizing both CaBP1 and caldendrin was absent in the brain of C-KO mice, but was intense in multiple brain regions of wild-type mice. By Western blot, the antibodies detected two proteins that were absent in the C-KO mouse and consistent in size w","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-04-19T16:37:22.539Z","creation":"2019-03-27T01:30:21Z"},"accession":"S-EPMC4060604","cross_references":{"pubmed":["24631676"],"doi":["10.1016/j.neuroscience.2014.02.052"]}}