{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["111(23)"],"submitter":["Tamzalit F"],"pubmed_abstract":["Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15Rα fusion protein, and found that IL-15 is detectable within responding cells following IL-15 trans-presentation. The role of the proteolytic cleavage of IL-15Rα in this process was investigated by generating an uncleavable form of IL-15Rα. We showed that IL-15 entry into responding cells necessitates the"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["8565-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4060713"],"repository":["biostudies-literature"],"pubmed_title":["IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells."],"pmcid":["PMC4060713"],"pubmed_authors":["Mortier E","Jacques Y","Heim J","Plet A","Tamzalit F","Nedellec S","Morisseau S","Barbieux I"],"additional_accession":[]},"is_claimable":false,"name":"IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.","description":"Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding cells integrate, or take advantage of this process has not been evaluated yet. To address this question, we set up a trans-presentation model using a membrane-bound IL-15.IL-15Rα fusion protein, and found that IL-15 is detectable within responding cells following IL-15 trans-presentation. The role of the proteolytic cleavage of IL-15Rα in this process was investigated by generating an uncleavable form of IL-15Rα. We showed that IL-15 entry into responding cells necessitates the","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-05T13:37:30.805Z","creation":"2019-03-27T01:30:21Z"},"accession":"S-EPMC4060713","cross_references":{"pubmed":["24912180"],"doi":["10.1073/pnas.1405514111"]}}