{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Smith IJ"],"funding":["NICHD NIH HHS"],"pagination":["2790-803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4062832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may have clinical benefit. The aim of the current study was to investigate the role of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in CMV-mediated diaphragm wasting and weakness in rats. CMV-induced diaphragm atrophy and contractile dysfunction coincided with marked increases in STAT3 phosphorylation on both tyrosine 705 (Tyr705) and serine 727 (Ser727). STAT3 activation was accompanied by its translocation into mitochondria within diaphragm muscl"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction."],"pmcid":["PMC4062832"],"funding_grant_id":["T32 HD043730"],"pubmed_authors":["White KA","Friera AM","Creger DP","Alcantara RR","Yung SL","Baltgalvis KA","Payan DG","Ding R","Wiggs MP","Powers SK","Ho MS","Romero JM","Chen Y","Singh R","Sollanek KJ","Gururaja T","Claypool MD","Taylor VC","McLaughlin JR","Hansen D","Smuder AJ","Godinez GL","Gelman MS","Nguyen HN","Kwon OS","Singh BK","Li W","Masuda ES","Smith IJ","Kinsella TM","Kinoshita T","McCaughey KM","Lang W","Yam GC"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction.","description":"Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic strategies for preventing these processes may have clinical benefit. The aim of the current study was to investigate the role of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in CMV-mediated diaphragm wasting and weakness in rats. CMV-induced diaphragm atrophy and contractile dysfunction coincided with marked increases in STAT3 phosphorylation on both tyrosine 705 (Tyr705) and serine 727 (Ser727). STAT3 activation was accompanied by its translocation into mitochondria within diaphragm muscl","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2025-04-22T17:39:56.244Z","creation":"2019-03-27T01:30:26Z"},"accession":"S-EPMC4062832","cross_references":{"pubmed":["24671708"],"doi":["10.1096/fj.13-244210"]}}