{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng DJ"],"funding":["NCI NIH HHS","NIH"],"pagination":["600-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4063277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["394(3)"],"pubmed_abstract":["The mechanism of cisplatin resistance in cancer cells is not fully understood. Here, we show that the Akt/mTOR survival pathway plays an important role in cisplatin resistance in human ovarian cancer cells. Specifically, we found that cisplatin treatment activates the Akt/mTOR survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes ovarian cancer cells to cisplatin. Furthermore, we generated cisplatin-resistant cells and found that resistant cells express a higher level of activated Akt as compared to their cisplatin sensitive counterparts. Importantly, inhibition of Akt or mTOR sensitized resistant cells to cisplatin-induced apoptosis. Taken together, our data indicate that activation of the Akt/mTOR pathway prevents cisplatin-ind"],"journal":["Biochemical and biophysical research communications"],"pubmed_title":["Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells."],"pmcid":["PMC4063277"],"funding_grant_id":["R01 CA100073"],"pubmed_authors":["Peng DJ","Zhou JY","Wu GS","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells.","description":"The mechanism of cisplatin resistance in cancer cells is not fully understood. Here, we show that the Akt/mTOR survival pathway plays an important role in cisplatin resistance in human ovarian cancer cells. Specifically, we found that cisplatin treatment activates the Akt/mTOR survival pathway and that inhibition of this pathway by the PI3K inhibitor LY294002 or knockdown of Akt sensitizes ovarian cancer cells to cisplatin. Furthermore, we generated cisplatin-resistant cells and found that resistant cells express a higher level of activated Akt as compared to their cisplatin sensitive counterparts. Importantly, inhibition of Akt or mTOR sensitized resistant cells to cisplatin-induced apoptosis. Taken together, our data indicate that activation of the Akt/mTOR pathway prevents cisplatin-ind","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2025-05-29T15:58:48.38Z","creation":"2025-05-29T15:58:48.38Z"},"accession":"S-EPMC4063277","cross_references":{"pubmed":["20214883"],"doi":["10.1016/j.bbrc.2010.03.029"]}}