{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guzman E"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["208-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4065783"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["193(1)"],"pubmed_abstract":["In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. In contrast, the γδ T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4(+)CD25(high) Foxp3(+) T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. IL-10-expressing γδ T cells inhibit Ag-specific and nonspecific proliferation of CD4(+) and CD8(+) T cells in vitro. APC subsets expressing IL-10 and TFG-β regulate proliferation of γδ T cells producing IL-10. We propose that γδ T cells are a major regulatory T cell population in the bovine system."],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Bovine γδ T cells are a major regulatory T cell subset."],"pmcid":["PMC4065783"],"funding_grant_id":["BBS/E/I/00001373","BBS/E/I/00001709","BB/D001536/1","BBS/E/D/20231762","BB/F013590/1","BB/H531135/1","BBS/E/I/00001715"],"pubmed_authors":["Smith AL","Taylor G","Cubillos-Zapata C","Guzman E","Hope J","Charleston B"],"additional_accession":[]},"is_claimable":false,"name":"Bovine γδ T cells are a major regulatory T cell subset.","description":"In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. In contrast, the γδ T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4(+)CD25(high) Foxp3(+) T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. IL-10-expressing γδ T cells inhibit Ag-specific and nonspecific proliferation of CD4(+) and CD8(+) T cells in vitro. APC subsets expressing IL-10 and TFG-β regulate proliferation of γδ T cells producing IL-10. We propose that γδ T cells are a major regulatory T cell population in the bovine system.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2024-10-15T21:49:33.934Z","creation":"2019-03-26T23:43:01Z"},"accession":"S-EPMC4065783","cross_references":{"pubmed":["24890724"],"doi":["10.4049/jimmunol.1303398"]}}