{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brisco MA"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","PHS HHS"],"pagination":["68-75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4067252"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["The long-term durability and prognostic significance of improvement in renal function after mechanical circulatory support (MCS) has yet to be characterized in a large multicenter population. The primary goals of this analysis were to describe serial post-MCS changes in estimated glomerular filtration rate (eGFR) and determine their association with all-cause mortality.Adult patients enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) with serial creatinine levels available (n=3363) were studied. Early post-MCS, eGFR improved substantially (median improvement, 48.9%; P<0.001) with 22.3% of the population improving their eGFR by ?100% within the first few weeks. However, in the majority of patients, this improvement was transient, and by 1 year, eGFR was only 6.7% above the pre-MCS value (P<0.001). This pattern of early improvement followed by deterioration in eGFR was observed with both pulsatile and continuous-flow devices. Interestingly, poor survival was associated with both marked improvement (adjusted hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.19-2.26; P=0.002) and worsening in eGFR (adjusted HR, 1.63; 95% CI, 1.15-2.13; P=0.004).Post-MCS, early improvement in renal function is common but seems to be largely transient and not necessarily indicative of an improved prognosis. This pattern was observed with both pulsatile and continuous-flow devices. Additional research is necessary to better understand the mechanistic basis for these complex post-MCS changes in renal function and their associated survival disadvantage.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00119834."],"journal":["Circulation. Heart failure"],"pubmed_title":["Prevalence and prognostic importance of changes in renal function after mechanical circulatory support."],"pmcid":["PMC4067252"],"funding_grant_id":["HHSN268201100025C","K23 HL114868","T32 HL007843","K24DK090203","1K23HL114868-02","5T32HL007843-15","K24 DK090203","5T32HL007891","T32 HL007891"],"pubmed_authors":["Coca SG","Parikh CR","Brisco MA","Putt ME","Tang WW","Jessup M","Kimmel SE","Testani JM"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence and prognostic importance of changes in renal function after mechanical circulatory support.","description":"The long-term durability and prognostic significance of improvement in renal function after mechanical circulatory support (MCS) has yet to be characterized in a large multicenter population. The primary goals of this analysis were to describe serial post-MCS changes in estimated glomerular filtration rate (eGFR) and determine their association with all-cause mortality.Adult patients enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) with serial creatinine levels available (n=3363) were studied. Early post-MCS, eGFR improved substantially (median improvement, 48.9%; P<0.001) with 22.3% of the population improving their eGFR by ?100% within the first few weeks. However, in the majority of patients, this improvement was transient, and by 1 year, eGFR was only 6.7% above the pre-MCS value (P<0.001). This pattern of early improvement followed by deterioration in eGFR was observed with both pulsatile and continuous-flow devices. Interestingly, poor survival was associated with both marked improvement (adjusted hazard ratio [HR], 1.64; 95% confidence interval [CI], 1.19-2.26; P=0.002) and worsening in eGFR (adjusted HR, 1.63; 95% CI, 1.15-2.13; P=0.004).Post-MCS, early improvement in renal function is common but seems to be largely transient and not necessarily indicative of an improved prognosis. This pattern was observed with both pulsatile and continuous-flow devices. Additional research is necessary to better understand the mechanistic basis for these complex post-MCS changes in renal function and their associated survival disadvantage.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00119834.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2020-10-29T14:02:12Z","creation":"2019-03-27T01:30:41Z"},"accession":"S-EPMC4067252","cross_references":{"pubmed":["24214901"],"doi":["10.1161/circheartfailure.113.000507","10.1161/CIRCHEARTFAILURE.113.000507"]}}