{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Bzdrenga J"],"pubmed_abstract":["<h4>Background</h4>SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity.<h4>Results</h4>Here, we present a comprehensive and broad enzymatic characterization of the natural lactonase and promiscuous organophosphorus hydrolase activities of SacPox, as well as a structural analysis using a model.<h4>Conclusion</h4>Kinetic experiments show that SacPox is a proficient lactonase, including at roo"],"journal":["BMC research notes"],"pagination":["333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4068969"],"repository":["biostudies-literature"],"pubmed_title":["SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase."],"pmcid":["PMC4068969"],"pubmed_authors":["Gotthard G","Champion C","Hiblot J","Chabriere E","Bzdrenga J","Elias M"],"additional_accession":[]},"is_claimable":false,"name":"SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase.","description":"<h4>Background</h4>SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity.<h4>Results</h4>Here, we present a comprehensive and broad enzymatic characterization of the natural lactonase and promiscuous organophosphorus hydrolase activities of SacPox, as well as a structural analysis using a model.<h4>Conclusion</h4>Kinetic experiments show that SacPox is a proficient lactonase, including at roo","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2026-05-04T07:48:34.53Z","creation":"2019-03-27T01:30:46Z"},"accession":"S-EPMC4068969","cross_references":{"pubmed":["24894602"],"doi":["10.1186/1756-0500-7-333"]}}