{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Anwer MU"],"funding":["Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["Natural selection of variants within the Arabidopsis thaliana circadian clock can be attributed to adaptation to varying environments. To define a basis for such variation, we examined clock speed in a reporter-modified Bay-0 x Shakdara recombinant inbred line and localized heritable variation. Extensive variation led us to identify EARLY FLOWERING3 (ELF3) as a major quantitative trait locus (QTL). The causal nucleotide polymorphism caused a short-period phenotype under light and severely dampened rhythm generation in darkness, and entrainment alterations resulted. We found that ELF3-Sha protein failed to properly localize to the nucleus, and its ability to accumulate in darkness was compromised. Evidence was provided that the ELF3-Sha allele originated in Central Asia. Collectively, we sh"],"journal":["eLife"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4071560"],"repository":["biostudies-literature"],"pubmed_title":["Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock."],"pmcid":["PMC4071560"],"funding_grant_id":["DA 1061/4-1","SFB635","SPP1530"],"pubmed_authors":["Davis SJ","Herrero E","Velikkakam James G","Boikoglou E","Nagy F","Davis AM","Hallstein M","Anwer MU"],"additional_accession":[]},"is_claimable":false,"name":"Natural variation reveals that intracellular distribution of ELF3 protein is associated with function in the circadian clock.","description":"Natural selection of variants within the Arabidopsis thaliana circadian clock can be attributed to adaptation to varying environments. To define a basis for such variation, we examined clock speed in a reporter-modified Bay-0 x Shakdara recombinant inbred line and localized heritable variation. Extensive variation led us to identify EARLY FLOWERING3 (ELF3) as a major quantitative trait locus (QTL). The causal nucleotide polymorphism caused a short-period phenotype under light and severely dampened rhythm generation in darkness, and entrainment alterations resulted. We found that ELF3-Sha protein failed to properly localize to the nucleus, and its ability to accumulate in darkness was compromised. Evidence was provided that the ELF3-Sha allele originated in Central Asia. Collectively, we sh","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2025-06-01T12:19:02.402Z","creation":"2025-06-01T12:19:02.402Z"},"accession":"S-EPMC4071560","cross_references":{"pubmed":["24867215"],"doi":["10.7554/eLife.02206"]}}