biostudies-literatureChen KNIBIB NIH HHSNIGMS NIH HHS6492-6495https://www.ebi.ac.uk/biostudies/studies/S-EPMC4073475biostudies-literatureUnknown6(12)We demonstrate that ligand hydrophobicity can be used to increase affinity and selectivity of binding between monolayer-protected cationic gold nanoparticles and β-lactoglobulin protein isoforms containing two amino acid mutations.NanoscaleOptimizing the selective recognition of protein isoforms through tuning of nanoparticle hydrophobicity.PMC4073475R01 GM077173EB014277R01 EB014277GM077173Rana SChen KGuo XRotello VMMoyano DFXu YfalseOptimizing the selective recognition of protein isoforms through tuning of nanoparticle hydrophobicity.We demonstrate that ligand hydrophobicity can be used to increase affinity and selectivity of binding between monolayer-protected cationic gold nanoparticles and β-lactoglobulin protein isoforms containing two amino acid mutations.2014-01-01T00:00:00Z2014 Jun2024-11-13T06:19:42.247Z2019-03-27T01:30:58ZS-EPMC40734752483861110.1039/c4nr01085j