{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["99(7)"],"submitter":["Domenech C"],"pubmed_abstract":["Dexamethasone could be more effective than prednisolone at similar anti-inflammatory doses in the treatment of childhood acute lymphoblastic leukemia. In order to check if this \"superiority\" of dexamethasone might be dose-dependent, we conducted a randomized phase III trial comparing dexamethasone (6 mg/m(2)/day) to prednisolone (60 mg/m(2)/day) in induction therapy. All newly diagnosed children and adolescents with acute lymphoblastic leukemia in the 58951 EORTC trial were randomized on prephase day 1 or day 8. The main endpoint was event-free survival; secondary endpoints were overall survival and toxicity. A total of 1947 patients with acute lymphoblastic leukemia were randomized. At a median follow-up of 6.9 years, the 8-year event-free survival rate was 81.5% in the dexamethasone arm "],"journal":["Haematologica"],"pagination":["1220-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4077084"],"repository":["biostudies-literature"],"pubmed_title":["Dexamethasone (6 mg/m2/day) and prednisolone (60 mg/m2/day) were equally effective as induction therapy for childhood acute lymphoblastic leukemia in the EORTC CLG 58951 randomized trial."],"pmcid":["PMC4077084"],"pubmed_authors":["Girard S","Ferster A","Munzer M","De Moerloose B","Lutz P","Philippet P","Children's Leukemia Group (CLG) of European Organisation for Research and Treatment of Cancer (EORTC)","Mazingue F","Plantaz D","Rohrlich P","Benoit Y","Yakouben K","Sirvent N","Suciu S","Uyttebroeck A","Bertrandfor Y","Domenech C","Plat G","Cave H","Millot F","Dastugue N"],"additional_accession":[]},"is_claimable":false,"name":"Dexamethasone (6 mg/m2/day) and prednisolone (60 mg/m2/day) were equally effective as induction therapy for childhood acute lymphoblastic leukemia in the EORTC CLG 58951 randomized trial.","description":"Dexamethasone could be more effective than prednisolone at similar anti-inflammatory doses in the treatment of childhood acute lymphoblastic leukemia. In order to check if this \"superiority\" of dexamethasone might be dose-dependent, we conducted a randomized phase III trial comparing dexamethasone (6 mg/m(2)/day) to prednisolone (60 mg/m(2)/day) in induction therapy. All newly diagnosed children and adolescents with acute lymphoblastic leukemia in the 58951 EORTC trial were randomized on prephase day 1 or day 8. The main endpoint was event-free survival; secondary endpoints were overall survival and toxicity. A total of 1947 patients with acute lymphoblastic leukemia were randomized. At a median follow-up of 6.9 years, the 8-year event-free survival rate was 81.5% in the dexamethasone arm ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2025-06-01T02:58:34.087Z","creation":"2019-03-27T01:31:11Z"},"accession":"S-EPMC4077084","cross_references":{"pubmed":["24727815"],"doi":["10.3324/haematol.2014.103507"]}}