biostudies-literatureUnknown14Fu W<h4>Background</h4>Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment. Human four-and-a-half LIM domain protein 1C (FHL1C) (KyoT2 in mice) has been demonstrated to suppress Notch activation in vitro, suggesting that FHL1C may be new candidate target in T-ALL therapy. However, the role of FHL1C in T-ALL cells remained unclear.<h4>Methods</h4>Using RT-PCR, we amplified full-length human FHL1C, and conBMC cancer463https://www.ebi.ac.uk/biostudies/studies/S-EPMC4077834biostudies-literatureFHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.PMC4077834Zhao JLYu HCLi SZFu WHuang SYLiang LHan HQin HYLin YLiang YMWang KfalseFHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.<h4>Background</h4>Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment. Human four-and-a-half LIM domain protein 1C (FHL1C) (KyoT2 in mice) has been demonstrated to suppress Notch activation in vitro, suggesting that FHL1C may be new candidate target in T-ALL therapy. However, the role of FHL1C in T-ALL cells remained unclear.<h4>Methods</h4>Using RT-PCR, we amplified full-length human FHL1C, and con2014-01-01T00:00:00Z2014 Jun2026-05-03T23:27:09.112Z2019-03-27T01:31:14ZS-EPMC40778342495287510.1186/1471-2407-14-463