{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jones-Lopez EC"],"funding":["NIAID NIH HHS"],"pagination":["e100984"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4079704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(7)"],"pubmed_abstract":["<h4>Rationale</h4>The degree to which tuberculosis (TB) is transmitted between persons is variable. Identifying the factors that contribute to transmission could provide new opportunities for TB control. Transmission is influenced by host, bacterial and environmental factors. However, distinguishing their individual effects is problematic because measures of disease severity are tightly correlated, and assessing the virulence of Mycobacterium tuberculosis isolates is complicated by epidemiological and clinical confounders.<h4>Objectives</h4>To overcome these problems, we investigated factors potentially associated with TB transmission within households.<h4>Methods</h4>We evaluated patients with smear-positive (≥2+), pulmonary TB and classified M. tuberculosis strains into single nucleotide"],"journal":["PloS one"],"pubmed_title":["Importance of cough and M. tuberculosis strain type as risks for increased transmission within households."],"pmcid":["PMC4079704"],"funding_grant_id":["U01 AI065663","U01 AI065663-01"],"pubmed_authors":["Ellner JJ","Hadad DJ","Dietze R","Jones-Lopez EC","Kim S","Salgame P","Molina LP","Chakravorty S","Gaeddert M","Palaci M","Marques-Rodrigues P","Moine S","Reilly N","Alland D","Vinhas S","Ribeiro-Rodrigues R","Fregona G"],"additional_accession":[]},"is_claimable":false,"name":"Importance of cough and M. tuberculosis strain type as risks for increased transmission within households.","description":"<h4>Rationale</h4>The degree to which tuberculosis (TB) is transmitted between persons is variable. Identifying the factors that contribute to transmission could provide new opportunities for TB control. Transmission is influenced by host, bacterial and environmental factors. However, distinguishing their individual effects is problematic because measures of disease severity are tightly correlated, and assessing the virulence of Mycobacterium tuberculosis isolates is complicated by epidemiological and clinical confounders.<h4>Objectives</h4>To overcome these problems, we investigated factors potentially associated with TB transmission within households.<h4>Methods</h4>We evaluated patients with smear-positive (≥2+), pulmonary TB and classified M. tuberculosis strains into single nucleotide","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-05-31T23:29:48.142Z","creation":"2025-05-31T23:29:48.142Z"},"accession":"S-EPMC4079704","cross_references":{"pubmed":["24988000"],"doi":["10.1371/journal.pone.0100984"]}}