{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan F"],"funding":["NIAID NIH HHS","Crohn's & Colitis Foundation"],"pagination":["555-69"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4083097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(6)"],"pubmed_abstract":["Posttranslational modification by ubiquitin tagging is crucial for regulating the stability, activity and cellular localization of many target proteins involved in processes including DNA repair, cell cycle progression, protein quality control, and signal transduction. It has long been appreciated that ubiquitin-mediated events are important for certain signaling pathways leading to leukocyte activation and the stimulation of effector function. Now it is clear that the activities of molecules and pathways central to immune regulation are also modified and controlled by ubiquitin tagging. Among the mechanisms of immune control, regulatory T cells (or Tregs) are themselves particularly sensitive to such regulation. E3 ligases and deubiquitinases both influence Tregs through their effects on "],"journal":["Journal of molecular medicine (Berlin, Germany)"],"pubmed_title":["Ubiquitous points of control over regulatory T cells."],"pmcid":["PMC4083097"],"funding_grant_id":["R01AI089830","3719","R01 AI099300","R01AI099300","R01 AI089830"],"pubmed_authors":["Barbi J","Pan F"],"additional_accession":[]},"is_claimable":false,"name":"Ubiquitous points of control over regulatory T cells.","description":"Posttranslational modification by ubiquitin tagging is crucial for regulating the stability, activity and cellular localization of many target proteins involved in processes including DNA repair, cell cycle progression, protein quality control, and signal transduction. It has long been appreciated that ubiquitin-mediated events are important for certain signaling pathways leading to leukocyte activation and the stimulation of effector function. Now it is clear that the activities of molecules and pathways central to immune regulation are also modified and controlled by ubiquitin tagging. Among the mechanisms of immune control, regulatory T cells (or Tregs) are themselves particularly sensitive to such regulation. E3 ligases and deubiquitinases both influence Tregs through their effects on ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-19T16:47:35.122Z","creation":"2020-11-07T09:50:29Z"},"accession":"S-EPMC4083097","cross_references":{"pubmed":["24777637"],"doi":["10.1007/s00109-014-1156-z"]}}