{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ganesh SK"],"funding":["NCATS NIH HHS","Cancer Research UK","NIDDK NIH HHS","Medical Research Council","NHLBI NIH HHS","National Institute for Health Research (NIHR)"],"pagination":["49-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4085637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(1)"],"pubmed_abstract":["Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23"],"journal":["American journal of human genetics"],"pubmed_title":["Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations."],"pmcid":["PMC4085637"],"funding_grant_id":["G1000143","G9521010","UL1 TR000124","NF-SI-0512-10113","NF-SI-0512-10114","G0401527","MR/K006584/1","P30 DK063491","14136","R01 HL105756"],"pubmed_authors":["Crawford GJ","Psaty BM","Allione A","Uiterwaal CS","Uitterlinden AG","Wain LV","Wichmann HE","Franco OH","Navis G","Eyheramendy S","Pfeufer A","Luan J","Zhao JH","Polidoro S","Yuan X","Global Blood Pressure Genetics Consortium","Schwartz SM","Groop L","Lorbeer R","Xu M","Kathiresan S","Loos RJ","Palmas W","Vineis P","Watkins H","Levy D","McArdle WL","Zeggini E","Lakatta EG","Coin L","Collins FS","Altshuler D","Jackson AU","Matullo G","Hartikainen AL","Scheet P","Khaw KT","Munroe PB","Hwang SJ","Eiriksdottir G","Ehret G","Smith AV","Raffel LJ","Ridker PM","Reffelmann T","Bonnycastle LL","Numans ME","Rivadeneira F","Volker U","Panico S","Kuusisto J","Dominiczak A","Bis JC","Boehnke M","Witteman JC","Vollenweider P","Jousilahti P","Papanicolau GJ","Lathrop GM","Rose LM","Papadakis K","Mohlke KL","Perola M","Rotter JI","Orho-Melander M","Pouta A","Romanazzi V","Sanna S","Pihur V","Hercberg S","Vaidya D","Syvanen AC","Doring A","Subirana I","Li G","Gieger C","Onland-Moret NC","Sijbrands EJ","Jarvelin MR","Samani NJ","Huo Y","Wallace C","Fornage M","van Gilst WH","Liu K","Sacerdote C","Johnson T","Illig T","Najjar SS","de Jong PE","Paterson AD","Freimer NB","Bingham SA","Stringham HM","Kooner JS","Homuth G","O'Donnell CJ","Grobbee DE","Williams FM","Snieder H","Ricceri F","Yang ML","Zhang Y","Launer LJ","Berglund G","Newton-Cheh C","Bergman RN","Meneton P","Lim N","McCarthy MI","Zhang F","Volzke H","Guo X","Siscovick DS","Rice K","Zhang H","Melander O","Gudnason V","Morrison AC","van der Schouw YT","Chasman DI","Larson MG","Lucas G","Rettig R","Laan M","Peden JF","Guarrera S","Dehghan A","Felix SB","Forouhi NG","Zeleneka D","Tognoni G","Verwoert G","Harris TB","Newhouse SJ","Laakso M","Voight BF","Bergmann S","Tobin MD","Amin N","Salomaa V","Bochud M","Galan P","Deloukas P","Tanaka T","Bouchard C","Hofman A","Heath SC","Wareham NJ","Burton PR","Goel A","Elliott KS","Org E","Ganesh SK","Valle TT","Marrugat J","Scott LJ","Sandhu MS","Beckmann JS","Teumer A","Peltonen L","Johnson AD","Clarke R","Boerwinkle E","Abecasis GR","Elliott P","Gut IG","Ferrucci L","Spector TD","Meitinger T","Barroso I","Vasan RS","Webster J","Waeber G","Farrall M","Seedorf U","Mooser V","Hamsten A","Gao W","Tuomilehto J","Di Gregorio A","Dorr M","Willer CJ","Morken MA","Bots ML","van Duijn C","Song K","Ernst F","O'Reilly PF","Bandinelli S","Luben RN","Schlessinger D","Waterworth DM","Soranzo N","van der Harst P","Chakravarti A","Uda M","Gu X","Gateva V","Zhai G","Strachan DP","Caulfield M","Hadley D","Elosua R","Chambers JC","Brown M","Scuteri A","Connell JM","Nilsson P"],"additional_accession":[]},"is_claimable":false,"name":"Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.","description":"Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-04-07T14:53:07.966Z","creation":"2019-03-27T01:31:36Z"},"accession":"S-EPMC4085637","cross_references":{"pubmed":["24975945"],"doi":["10.1016/j.ajhg.2014.06.002"]}}