{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Arbel Y"],"pubmed_abstract":["<h4>Background</h4>Acute kidney injury (AKI) is observed in up to 41% of patients undergoing transcatheter aortic valve implantation (TAVI) and is associated with increased risk for mortality. The aim of the present study is to evaluate whether furosemide-induced diuresis with matched isotonic intravenous hydration using the RenalGuard system reduces AKI in patients undergoing TAVI.<h4>Methods/design</h4>Reduce-AKI is a randomized sham-controlled study designed to examine the effect of an automated matched hydration system in the prevention of AKI in patients undergoing TAVI. Patients will be randomized in a 1:1 fashion to the RenalGuard system (active group) versus non-matched saline infusion (sham-controlled group). Both arms receive standard overnight saline infusion and N-acetyl cystei"],"journal":["Trials"],"pagination":["262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4086440"],"repository":["biostudies-literature"],"pubmed_title":["Forced diuresis with matched hydration in reducing acute kidney injury during transcatheter aortic valve implantation (Reduce-AKI): study protocol for a randomized sham-controlled trial."],"pmcid":["PMC4086440"],"pubmed_authors":["Schwartz AL","Arbel Y","Konigstein M","Finkelstein A","Banai S","Ben-Assa E","Keren G","Leshem-Rubinow E","Havakuk O","Steinvil A","Halkin A","Abramowitz Y"],"additional_accession":[]},"is_claimable":false,"name":"Forced diuresis with matched hydration in reducing acute kidney injury during transcatheter aortic valve implantation (Reduce-AKI): study protocol for a randomized sham-controlled trial.","description":"<h4>Background</h4>Acute kidney injury (AKI) is observed in up to 41% of patients undergoing transcatheter aortic valve implantation (TAVI) and is associated with increased risk for mortality. The aim of the present study is to evaluate whether furosemide-induced diuresis with matched isotonic intravenous hydration using the RenalGuard system reduces AKI in patients undergoing TAVI.<h4>Methods/design</h4>Reduce-AKI is a randomized sham-controlled study designed to examine the effect of an automated matched hydration system in the prevention of AKI in patients undergoing TAVI. Patients will be randomized in a 1:1 fashion to the RenalGuard system (active group) versus non-matched saline infusion (sham-controlled group). Both arms receive standard overnight saline infusion and N-acetyl cystei","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2025-04-18T14:44:49.783Z","creation":"2019-03-27T01:31:41Z"},"accession":"S-EPMC4086440","cross_references":{"pubmed":["24986373"],"doi":["10.1186/1745-6215-15-262"]}}