{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chagnon-Choquet J"],"funding":["Alberta Innovates","Canadian Institutes of Health Research"],"pagination":["e101949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4087016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(7)"],"pubmed_abstract":["Understanding how the immune system facilitates or controls HIV-1 disease progression has important implications for the design of effective interventions. We report that although B-cell dysregulations associated with HIV-1 disease progression are accompanied by an overall decrease in the percentage of total blood B-cells, we observe an increase in relative frequencies of cells presenting characteristics of both transitional immature and first-line marginal zone (MZ) B-cell populations, we designated as precursor MZ-like B-cells. B-cells with similar attributes have been associated with IL-10 expression and \"regulatory\" potential. As such, the relative frequencies of precursor MZ-like B-cells expressing IL-10 are increased in the blood of viremic HIV-1-infected individuals when compared to"],"journal":["PloS one"],"pubmed_title":["IL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression."],"pmcid":["PMC4087016"],"funding_grant_id":["126633","201201140"],"pubmed_authors":["Vezina S","Huchet E","Bernard N","Lessard B","Rouleau D","Roger M","Cote P","Poudrier J","Baril JG","Charron MA","Bruneau J","Potter M","Charest L","lalonde R","Thomas R","Vassal A","Munoz M","Milne C","Tremblay C","Slow Progressor Study Group","Legault M","Gilmore N","Szabo J","Klein M","Montreal Primary HIV Infection Study Group","Fontaine J","de Pokomandy A","Labrecque L","Fortin C","Trottier B","Friedman J","Routy JP","Dufresne S","LeBlanc R","Chagnon-Choquet J"],"additional_accession":[]},"is_claimable":false,"name":"IL-10 and lymphotoxin-α expression profiles within marginal zone-like B-cell populations are associated with control of HIV-1 disease progression.","description":"Understanding how the immune system facilitates or controls HIV-1 disease progression has important implications for the design of effective interventions. We report that although B-cell dysregulations associated with HIV-1 disease progression are accompanied by an overall decrease in the percentage of total blood B-cells, we observe an increase in relative frequencies of cells presenting characteristics of both transitional immature and first-line marginal zone (MZ) B-cell populations, we designated as precursor MZ-like B-cells. B-cells with similar attributes have been associated with IL-10 expression and \"regulatory\" potential. As such, the relative frequencies of precursor MZ-like B-cells expressing IL-10 are increased in the blood of viremic HIV-1-infected individuals when compared to","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-18T21:44:00.576Z","creation":"2019-03-26T23:26:26Z"},"accession":"S-EPMC4087016","cross_references":{"pubmed":["25003989"],"doi":["10.1371/journal.pone.0101949"]}}